pco.panda 4.2 sCMOS Camera

Revolutionary sCMOS technology in a compact design

The pco.panda is one of pco’s state-of-the-art sCMOS sensor camera systems, which have revolutionized the scientific camera market since their introduction in 2010.


With ultra-compact housing of roughly 65 x 65 x 65 mm³, the pco.panda 4.2 sCMOS camera system provides high quantum efficiency with low readout noise, making it suitable for countless applications.
In addition, the USB 3.1 interface has inherent advantages as it enables a new generation of cameras with ultra-speed data transfer and direct power via the USB cable, making external power supplies redundant. Use the pco.panda 4.2 sCMOS camera system with the latest software from PCO.

Key Features:

  • ultra-compact size: 65 x 65 x 65 mm³
  • latest 16 bit sCMOS sensor technology
  • high resolution 2048 x 2048 pixel
  • pixel size: 6.5 x 6.5 µm
  • low readout noise < 2 e- med
  • dynamic range of 22 500 : 1
  • quantum efficiency up to 80%
  • exposure times from 100 µs to 1s
  • maximum frame rate 40 fps @ full resolution
  • Rolling Shutter
  • USB 3.1 interface
  • power over USB

Quantum Efficiency Curves:

Quantum efficiency curve for pco.panda 4.2 monochrome.

Quantum efficiency curve for pco.panda 4.2 colour.


View/Download the datasheet here.


Area Applications:

  • brightfield microscopy
  • fluorescence microscopy
  • digital pathology
  • single molecule localization microscopy
  • lightsheet fluorescence microscopy (LSFM)
  • calcium imaging
  • FRET
  • FRAP
  • structured illumination microscopy (SIM)
  • high-speed bright field ratio imaging
  • high throughput screening
  • high content screening
  • biochip reading
  • TIRF microscopy
  • spinning disk confocal microscopy
  • 3D metrology
  • ophthalmology
  • industrial quality inspection

Application Example:

SMLM DNA Origami

DNA origami is a powerful method for the programmable assembly of nanoscale molecular structures. For applications of these structures as functional biomaterials, the study of reaction kinetics and dynamic processes in real time and with high spatial resolution becomes increasingly important. Read more here.


sCMOS Ebook:

View/download the PCO ebook “Everything you always wanted to know about sCMOS cameras”.

PCO Camware Tutorial Series:


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