pco.edge 5.5 sCMOS Camera

Cooled High Resolution Low Noise sCMOS  5.5 Megapixel Camera



The pco.edge 5.5 camera system is designed for users who require high resolution, high frame rates, best 16 bit dynamic range, delectable shutter variants and optionally a colour sensor. It is equipped with an innovative 5.5 megapixel scientific CMOS sensor which offers a large field of view and high resolution, without compromising read noise or frame rate. The system is air-cooled with the option to upgrade to a water cooling system. Camera Link HS guarantees uncompressed and secure data transfer. The latest standard of high-performance data interfaces enables the bridging of long distances via fiber optic cable. Alternatively, Camera Link full and USB 3.0 interfaces are also available. Use the pco.edge 5.5 sCMOS camera system with the latest software from PCO.

Key Features:

  • thermal stabilization at 0°C / +5 °C / +7 °C
  • extreme low readout noise of 1.0 e- med
  • high resolution of 2560 x 2160 pixel
  • dynamic range of 30 000 : 1 (CLHS, USB) / 27 000 : 1 (CL)
  • quantum efficiency up to 60%
  • exposure times from 500 µs to 2s (RS)
  • maximum frame rate 100 fps
  • rolling shutter or global shutter / global reset functionality
  • lightsheet mode
  • Camera Link HS, Camera Link full or USB 3.0 interface
  • monochrome or color sensor
  • small form factor: 102 x 79 x 70 mm
  • optional: water cooling system

Technical Specification:

Unit Setpointpco.edge 5.5
Resolution (hor x vert)pixel2560 x 2160
Pixel size (hor x vert)µm6.5 x 6.5
Peak Quantum Efficiency%@ 590 nm typ.> 60
Dynamic Range A/Dbit16
Readout Noisee- medUSB
Frame Ratefps@ full frame (USB)
@ full frame (CL/CLHS)
Exposure Time Range @ Rolling Shutter (CL)
@ Global Shutter (CL)
@ Global Reset (CL)
@ Rolling Shutter (USB)
@ Global Shutter (USB)
@ Global Reset (USB)
500 µs - 2 s
10 µs - 100 ms
10 µs - 2 s
500 µs - 2 s
20 µs - 100 ms
30 µs - 2 s
Region of Interest (ROI)selectable
Optical InputNikon F-mount,
Data InterfaceCamera Link HS,
Camera Link
(full, 10tap)
or USB 3.0

Quantum Efficiency Curve:

View / Download the datasheet here.

View / download the pco.edge range brochure

Application Areas:

  • brightfield microscopy
  • fluorescence microscopy
  • digital pathology
  • single molecule localization microscopy
  • lightsheet fluorescence microscopy (LSFM)
  • calcium imaging
  • FRET
  • FRAP
  • structured illumination microscopy (SIM)
  • high-speed bright field ratio imaging
  • high throughput screening
  • high content screening
  • biochip reading
  • TIRF microscopy
  • spinning disk confocal microscopy
  • 3D metrology
  • ophthalmology
  • photovoltaic inspection
  • industrial quality inspection
  • lucky astronomy
  • disaster recovery
  • tunnel inspection

Application Examples:

Modular Wafer Inspection with pco.edge 5.5

Silicon carbide (SiC) is a wide bandgap semiconductor, which is especially used for high-power, high-temperature and high-frequency devices due to its high energy efficiency. Despite great improvements in the material quality of SiC substrates and epitaxial wafers within the last years, critical defects like stacking faults (SFs) and basal plane dislocations (BPDs) can still lead to bipolar degradation and finally to complete failure of the device. Read more about this here.


Fluorensce Microscopy DNA Micro Arrays with pco.edge series

Microarrays are versatile tools for high throughput screening. Nevertheless they are severely limited. Either the molecules are synthesized in-situ directly on the surface or in-vitro or in-vivo produced externally and then transferred onto the surface. In-situ synthesis shows low yield in terms of purity and restricts therefore the biomolecule probe length to ~50 bp for light-synthesized DNA (Affymetrics) or ~200 bp print-synthesis (Agilent), but allows up to millions of spots per array. Ex-array synthesis on the other hand provides high-purity molecules, but the (bio)synthesis and purification of these molecules is tedious, time consuming and expansive. Also the printing process takes time. Even if one spot can be made per second 100,000 spots will take more than a day. Therefore the idea arose why to copy microarrays. Why not make DNA, RNA and protein microarrays as high quality copies of a high quality original? It worked fine for text books and images. So why not apply it for DNA? Why not build a biomolecule copying machine? A biomolecule xeroxer? Read more about this here.


Time Lapse 3D measurements with pco.edge series

Light sheet fluorescence microscopy has previously been demonstrated on a commercially available inverted fluorescence microscope frame using the method of oblique plane microscopy (OPM). In this paper, OPM is adapted to allow time-lapse 3-D imaging of 3-D biological cultures in commercially available glass-bottomed 96-well plates using a stage-scanning OPM approach (ssOPM). Read more about this here.


Particle Imaging Velocimetry Tour de France with pco.edge 5.5

Particle Image Velocimetry not only allows visualizing the airflow around the bike and rider, but also accurately measures the flow in detail. Development engineers use these results to optimize the performance of bike and clothing and help André Greipel in this way to reach new sportive achievements. Read more about this here.


EOS 3D Printing with pco.edge 5.5

Additive manufacturing is currently making a giant leap towards mass production. Technological processes have matured and industrial 3D printing has proven to be an efficient manufacturing process. EOS is launching an innovative quality monitoring solution for optical tomography. The heart of the system is the pco.edge sCMOS camera. Read more about this here.

Propeller Induced Properties with pco.edge 5.5/pco.4000

Multiple optical measurement techniques have been applied for the investigation of a propeller-wing wind tunnel model. The (half) wind tunnel model is equipped with a nine bladed propeller and its wing has active Coanda blowing over the whole span of the wing. Read more about this here.

sCMOS Ebook:

View/download the PCO ebook “Everything you always wanted to know about sCMOS cameras”.

PCO Camware Tutorial Series:


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